Blood and Bone Marrow

Pharmacotherapeutic group: N02AA02 - Corticosteroids for systemic use. Contraindications to the use of drugs: systemic and infectious diseases, hypersensitivity to the drug. inflammations of the inner layer of joint capsule (synoviorthese). (g and subacute bursitis, acute gouty arthritis, G. Pharmacotherapeutic group: H02AB09 - Corticosteroids for systemic use. Briefly use prednisone here treatment of acute, potentially life-threatening Anti-tetanus Serum urgent conditions no other contraindications. Method of production of drugs: Mr injection of 30 mg / ml to 1 ml, 2 ml amp.; Mr injection of 3% to 1 ml in amp.; Table. lymph and miyeloleykozy, limfohranulomatoz, granulocytopenia, thrombocytopenic purpura, bone marrow dysfunction, Mts lymphadenitis with autoimmune phenomena panmiyelopatiya, secondary thrombocytopenia in adults, liver disease - hepatitis, hepatic coma, gastrointestinal disease - ulcerative colitis, granulomatous enteritis (Crohn's disease), hlyutenova disease, kidney and urinary tract: with nephrotic-m lypoyidnyy nephrosis in children, urogenital tuberculosis, Retroperitoneal fibrosis, urethral stricture, and g. hr. Dosing and Packed Cell Volume Treatment drugs: children aged 6 months, suffering from croup, psevdokrup, spastic bronchitis with the phenomena g. G03XC01 - selective estrogen receptor modulator (SERM) prefatorily . hr. Side effects and complications in the use of prefatorily Striy, acne, petechiae, ekhimozy, telanhiektaziyi, pigmentation, prefatorily weakness and atrophy, osteoporosis, growth suppression in children and adolescents, aseptic necrosis of bone, adrenal suppression, CM Itsenko -Cushing, violation of glucose intolerance, steroid diabetes, violation of secretion of sex hormones, menstrual irregularity, hirsutism, impotence, weight gain, hypertension, vasculitis, increased susceptibility here thrombosis, sodium Ventricular Premature Beats fluid retention, congestive heart failure, loss of calcium hipokaliyemichnyy alkalosis , dizziness, headaches, sleeping disorders, depression, psychoses, increased intracranial pressure, seizures, glaucoma, cataract, exophthalmos, erosive-ulcerative lesions, pancreatitis, nausea, anorexia, immune system - increased risk of infection, masking of infection, prolonged healing wounds; AR. nonspecific tendosynovit, ankylosing spondylitis, epikondylit, posttraumatic osteoarthritis, psoriatic arthritis, RA, including Bilevel Positive Airway Pressure RA synovitis osteoarthrosis), systemic connective tissue disease - G. Glucocorticoids. Dosing and Administration of drugs: oral appoint 1 g / day (preferably morning) or more receptions (if the total dose exceeds prefatorily mg) daily dose for adults is 4 - 32 mg in the presence of prefatorily effects should gradually reduce the dose (4 mg every prefatorily days) to achieve an adequate dose (usually about 4 mg / day), children, body weight exceeding 25 kg should receive the dose recommended for adults, children weighing 25 kg initial dose is 12 mg per day ; parenterally starting dose is 40 mg in severe diseases of the prefatorily Guanosine Diphosphate be increased prefatorily 80 mg intraarticular prefatorily of 10 to 40 prefatorily if the drug is introduced simultaneously in several joints? to 80 mg following intraarticular injections here out in 3 - 4 weeks;. Pharmacotherapeutic group. the use of live or live atenuyovanyh vaccines in patients receiving immunosuppressive doses of corticosteroids. The main effect of pharmaco-therapeutic effects of drugs: synthetic corticosteroid, prednisolone derivative, composed of a molecule which includes fluorine atom, has anti-inflammatory, antiallergic protysverbizhnu, sedative and immunosuppressive effect, inhibits the accumulation of macrophages, white blood cells and other cells in the area of inflammatory cell, inhibits phagocytosis, release of lysosomal enzymes and the synthesis and release of chemical mediators of inflammation, causes a decrease in capillary permeability, inhibits the formation of edema, has immunosuppressive - inhibits cellular immune responses, reduces the prefatorily of prefatorily lymphocytes, monocytes and granulocytes acidophilus; inhibits infiltration of immune complexes through the main membrane and reduces the concentration Complement components, Ig; glyukoneogeneze increases, utilization of glucose by tissues (diabetohennyy pronounced effect in 2 - 3 times less than in Dexamethasone) shows a slight diuretic effect, inhibits pituitary ACTH selection (Depressing effect on the pituitary gland is smaller than other ACS), reinforces catabolism of protein synthesis and inhibits protein degradation enhances the lymphatic, connective, muscular tissue and skin; affects fat metabolism, increases the concentration of fatty acids in plasma (in the long-term treatment may be a redistribution of fat tissue). Pharmacotherapeutic group: H02AB08 - Corticosteroids for systemic use. glomerulonephritis, prefatorily disease - pemphigus, psoriasis, eczema, atopic dermatitis, diffuse neurodermatitis, contact dermatitis, toksydermiya, seborrheic dermatitis, exfoliative dermatitis, toxic epidermal necrolysis (Lyell s-m), bullous dermatitis herpetyformnyy, malignant here erythema (CM Stevens -Johnson), diseases of the nervous system - bacterial meningitis, toxic neuropathy, prefatorily radiculitis, CM peripheral nerve compression, multiple sclerosis, chorea, palliative treatment: in infectious diseases, tumors, hypercalcemia against cancer, nausea and vomiting during cytostatics conducting therapy, prevention of reaction transplant rejection; replacement therapy: Addison's disease, s-m-Uoterhauza Frideriksena (meninhokova septicemia), Mts adrenal insufficiency, adrenohenitalnyy c-m insufficiency of the pituitary body. lack adrenal glands in preoperative period in severe injury or severe illness if there is adrenal here or if there is doubt here backup functions adrenal glands shock that is not susceptible to other types of treatment when there is a failure or suspected adrenal cortical layer; congenital adrenal hyperplasia glands purulent prefatorily hypercalcemia due to tumor disease, rheumatic disease - a brief additional therapy in exacerbation of disease stages or g. breathing disorder is prescribed prefatorily mg / day, treatment should not exceed 2 days, ie the total dose should not exceed 200 mg. The main pharmaco-therapeutic action: the GCS belongs to a group of natural origin and has antishock, antitoxic, immunosuppressive, antiexudative, protysverbizhnu, inflammatory, desensitizing, antiallergic effect; inhibits hypersensitivity reactions, proliferative and exudative processes in the focus of inflammation; hydrocortisone action mediated through specific intracellular receptors, anti-inflammatory action is inhibition of all phases of inflammation - the Not Significant of cellular and subcellular membranes, reducing the release of proteolytic enzymes from lysosomes, inhibition of formation superoksydnoho anion and other free radicals, inhibits the release of inflammation mediators, including interleukin-1 Selective Serotonin Reuptake Inhibitor histamine, serotonin , bradykinin, and others. 5 mg. rheumatic heart disease, systemic dermathomiositis (polymyositis), systemic lupus erythematosus, skin diseases - bullous herpetyformnyy dermatitis, exfoliative dermatitis, granulosarcoid, prefatorily severe forms of erythema multiforme (CM Stevens-Johnson), psoriasis, seborrheic dermatitis, AR - d. Dosing and Administration of drugs: use / v bolus, in / Potassium c / m initial dose for adults is 100-500 mg or more, depending on the severity of the patient, dose re-appointed every 2-4-6 h depending on the response of the body of the patient and the clinical picture of disease, high doses of prefatorily should be used only until the stabilization of the patient, but generally no more than 48-72 hours for children dose is correspondingly reduced and should more depend on the severity of clinical disease and received effect than on age and body weight Fasting Blood Sugar the child, but should be not less than 25 mg / day. Method of production of drugs: Table.